Monday, August 24, 2015

B-Vitamins for Heart Health in Celiac folks

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Have you wondered whether or not there is another aspect of your health that needs to be addressed once you go gluten-free? Check out this study for a couple of vitamins that all celiacs/gluten intolerants should include in their lives.
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
by Hadithi M, Mulder CJ, Stam F, Azizi J, Crusius JB, Pena AS, Stehouwer CD, Smulders YM
Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease.
World J Gastroenterol. 2009 Feb 28;15(8):955-960
Authors: Hadithi M, Mulder CJ, Stam F, Azizi J, Crusius JB, Pena AS, Stehouwer CD, Smulders YM
AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003), folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. 
So make sure that you have enough B6, folate and B12 in your supplementation.

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